Micotil® (tilmicosin) Injection vs. Zelnate® DNA Immunostimulant1


Evaluate the efficacy of Zelnate versus a currently approved antibiotic [Micotil® 300 (tilmicosin) Injection] when administered for the control of BRD in feedlot cattle in medium risk conditions.

Study Procedures

In this study, healthy steers at medium risk of BRD were randomly allocated into two groups (n=1,002 per group). Cattle were classified as being at medium risk of BRD because they were heavier calves from multiple sources. All calves were from ranch/farm origin (5 Montana and 4 South Dakota ranches) and had traveled relatively short transport distances. Calves were administered their assigned treatment at arrival.

Zelnate group: Zelnate (2 mL) via intramuscular (IM) injection

Micotil group: Micotil (2 mL) via subcutaneous (SC) injection

In addition to their Micotil or Zelnate treatment, all enrolled calves received BRD and clostridial vaccinations, a deworming agent and a steroid implant. The following BRD therapy protocol was also implemented (3 days moratorium after Micotil/Zelnate):

  • 1st BRD event: Draxxin® (tulathromycin) Injectable Solution [moratorium 7 days]
  • 2nd BRD event: Baytril® 100 (enrofloxacin) Injectable [moratorium 2 days]
  • 3rd BRD event: Advocin® (danofloxacin injection) [“chronic BRD”]

After three BRD treatments the calf was considered chronic and no further antibiotic therapy was provided to that calf for BRD.


No statistical differences were found between treatment groups across all clinical and performance parameters.

SC = subcutaneous IM = intramuscular

Micotil vs. Zelnate


Different letters indicate differences of P < 0.05.

No statistical differences between treatment groups across all clinical and performance parameters.   In this study, the performance of Zelnate was similar to Micotil.

See the full technical report pdf

1Data on file. Bayer HealthCare Animal Health.

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